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KMID : 0648320080140010001
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Journal of The Korean Society of Hypertension
2008 Volume.14 No. 1 p.1 ~ p.8
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Altered nitric oxide system in the kidney in hypertension
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Lee Jong-Un
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Abstract
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Nitric oxide has been implicated in many physiologic processes that influence both short-term and long-term control
of renal function, such as regulation of glomerular hemodynamics, mediation of pressure-natriuresis, maintenance of
medullary perfusion, blunting of tubuloglomerular feedback, inhibition of tubular sodium reabsorption and modulation
of renal sympathetic nerve activity. Its net effect in the kidney is to promote natriuresis and diuresis, playing an
important role in the adaptation to variations of dietary salt intake and maintenance of normal blood pressure. A
reduced production and biological action of nitric oxide results in an elevation of arterial pressure, and conversely, an
exaggerated activity may represent a compensatory mechanism to ameliorate the hypertension.
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KEYWORD
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nitric oxide, pressure-natriuresis, tubuloglomerular feedback, renal failure, salt-sensitive hypertension
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